Diuretics in combination antihypertensive therapy: focus on forecast

Combination Therapy in Antihypertensive Treatment

One of the most prevalent and important disease worldwide is arterial hypertension with prevalence of 35-40%. When we look worldwide prevalence of hypertension in 2000, we can see that approximately 972 millions of people were with hypertension, and the estimation is that around 1560 millions of people in 2025 will have hypertension [1]. There is a linear association between increased blood pre...

Beta-blockers and diuretics in antihypertensive therapy: the debate continues.

BUMC PROCEEDINGS 2000;13:379–380 Editor’s note: In the April 2000 issue, Dr. Franz Messerli published an article entitled “Antihypertensive therapy: beta-blockers and diuretics— why do physicians not always follow guidelines?” BUMC Proceedings published commentaries to this article by Dr. Marvin Moser of Yale University School of Medicine and Dr. Norman Kaplan of The University of Texas Southwe...

Antihypertensive Therapy: Beta-Blockers and Diuretics - What is the Evidence?

Antihypertensive treatment with diuretics: antediluvian

Thiazide diuretics were among the first drugs able to lower blood pressure with minimal side-effects in a large proportion of the hypertensive population. In addition they appeared to potentiate nearly all other hypotensive drugs. Hence they were advised as the mainstay of antihypertensive treatment and were used in all large-scale trials [1] which showed beneficial effect of blood pressure low...

Mechanism of antihypertensive effect of thiazide diuretics.

Hemodynamic studies were carried out before and during 8 weeks of treatment with hydrochlorothiazide 50 mg. twice daily in 11 hypertensive patients. Forty-eight hours after beginning treatment there was a significant reduction in blood pressure, cardiac output, plasma volume, and extracellular fluid volume (thiocyanate space) while total peripheral resistance increased. After 6 and 8 weeks of t...